African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy.

نویسندگان

  • Jeffrey A Canter
  • Gregory K Robbins
  • Doug Selph
  • David B Clifford
  • Asha R Kallianpur
  • Robert Shafer
  • Shawn Levy
  • Deborah G Murdock
  • Marylyn D Ritchie
  • David W Haas
  • Todd Hulgan
چکیده

Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.

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عنوان ژورنال:
  • The Journal of infectious diseases

دوره 201 11  شماره 

صفحات  -

تاریخ انتشار 2010